U.S. West Texas Intermediate (WTI) crude futures were at $46.35 per barrel at 0155 GMT, down 9 cents from their last close.
Brent crude futures were down 7 cents, at $51.93 a barrel.
“Severe flooding due to tropical storm Harvey is affecting refinery capacity and therefore crude demand, with the largest refinery in the U.S. currently operating at just 60 percent capacity,” ANZ bank said in a note on Wednesday.
The largest crude oil refinery in the United States, operated by Motiva Enterprises, was shutting down on Tuesday night due to flooding from Harvey in its 603,000 barrel-per-day (bpd) Port Arthur plant in Texas, according to people familiar with operations.
Preparing for more rain and floods, Total cut production to 53 percent of capacity at its 225,500 bpd Port Arthur refinery, market sources said.
Hurricane Harvey hit the U.S. Gulf coast last Friday. While it has been downgraded to a tropical storm, ongoing torrential rains have flooded numerous refineries in Texas and Louisiana, the heart of the American petroleum industry.
At least 3.6 million bpd of refining capacity are offline in Texas and Louisiana, or nearly 20 percent of total U.S. capacity, based on company reports and Reuters estimates.
Restarting plants even under the best conditions can take a week or more, refiners said.
Fearing a gasoline supply crunch, U.S. gasoline prices rose to a more than two year high of $1.84 per gallon early on Wednesday. Source: Reuters