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Harbin, a Chinese city of 10 million people, has been put on lockdown after 70 new coronavirus infections were reported.
The city has restricted inbound traffic on Wednesday to control the spread of the highly contagious disease.
It is thought a student arriving from New York could be the source of the new outbreak in the city, according to state media.
Harbin has banned entry to residential zones by non-locals and vehicles registered elsewhere, state media reported.
It had already ordered isolation for those arriving from outside China or key epidemic areas, according to The Associated Press.